2. Give it a try! From a practical standpoint, drugs that have a large Vd will need to be administered in larger doses to achieve a target concentration in the plasma. As long as a drug is bound non-specifically to a protein, it cannot have a therapeutic action, nor can it be eliminated (metabolized hepatically by the liver or excreted by the kidneys). c) Lungs and kidney a) The concentration of a drug, tissue/blood partition coefficient of drug 7 hours c. 10 hours d. 12.5 hours e. 15 hours 11. Loading… Pharmaceutics MCQs Pharmaceutics MCQs The apparent volume of distribution, Vd, is mathematically calculated by dividing the dose that is administered (mg) by the plasma concentration (mg/L). The Art of Triathlon. a) True a) True b) Adults Of age more than 20 Physiology MCQs: Circulation 04/06/02 1. Warfarin. View Answer, 2. Who has higher fat content? b. Predictably reverses benzodiazepine induced respiratory depression. B. C. E. D. Physiology MCQs: Circulation. Featured post. Drugs with a Vd > 40 L distribute throughout all body tissues (vascular, extracellular, and intracellular fluid compartments). Now D.T of tablet is directly proportional to –amount o f binder -Compression force. Drugs will be more quickly distributed to areas of the body that receive large amounts of blood flow (e.g. T-4.8.5 Pharmacology-IV . formulation and evalution of enteric coated pellets of. The final module illustrates relationships between VD and loading dose. [import, manufacture, distribution and sale] of drugs 2 [and cosmetics]; AND WHEREAS the Legislature of all the Provinces have passed resolutions in terms of section 103 of t he G ov ern ment ofIndia Act, 1935 (26 o. On the other hand, once a drug reaches adipose tissue, it may remain distributed here for quite a while until plasma concentrations decline and the drug can move “down its concentration gradient” back into the blood stream (e.g. Participate in the Sanfoundry Certification contest to get free Certificate of Merit. Volume of distribution. This set has 23 slides and describes how lipid solubility, drug ionization, drug size, pH, and non-specific protein binding influence drug distribution throughout various body “compartments”. E 2. The European Medicines Agency's (EMA) provides answers to frequently asked questions on good manufacturing practice (GMP) and good distribution practice (GDP), as discussed and agreed by the GMP/GDP Inspectors Working Group.. Join our social networks below and stay updated with latest contests, videos, internships and jobs! d) A large amount of drug is needed as the person’s weight is more d) The high fatty acid level affect the binding of acidic drugs D) pharmacodynamics . b. Binds sparingly to plasma proteins. E 9. c) Lungs and kidney E 8. c. Is potentiated by flumazenil . 80. D . Different drugs have different ways in which they enter the body and attack the base for an illness or diseases. d) Blood density upon the tissue, tissue/blood partition coefficient of drug Click here to solve the MCQ MULTIPLE CHOICE QUESTIONS. B) dependent on the value of half-life. b) The mother needs more drug due to high metabolism anaesthesia uk sodium potassium and the anaesthetist. Is cleared renally. Diazepam. Drugs that have relatively small Vd (e.g. B. B 3. 40. Mechanism of drug action is explored by: A) pharmacokinetics. a) Aged d) Children at puberty a) The baby needs more drug b) The mother needs more drug due to high metabolism c) The surface area increases in the mother’s body due to the presence of uterus, placenta, and foetus. There is an assumption here; that is, calculation of the apparent Vd presumes that the drug concentration is the same everywhere throughout the body. Which of the following sentences describe the given fact better? ionization of a drug, lipophilicity of a drug, size of a drug, pH of the environment, etc.) Distribution of drugs to specific tissues (a) Is independent of blood flow to the organ (b) Is independent of the solubility of the drug in that tissue (c) Depends on the unbound drug concentration gradient between blood and tissue (d) Is increased for drugs that are strongly bound to plasma proteins (e) Has no effect on the half-life of the drug 5. Drupal site built by The University of Edinburgh, This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, The Merck Manual-Drug distribution to tissues, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. b) False View Answer, 8. D 6. Drugs with a Vd of 15L distribute throughout vascular and extracellular fluid compartments. 5 hours b. In the second module, users can inject drug and see what happens as drug distributes more widely throughout various compartments. Sanfoundry Global Education & Learning Series – Drug and Pharmaceutical Biotechnology. D. 160. The concept of “apparent volume of distribution” is a concept that seeks to predict how extensively a drug is distributed throughout the body. We know, in actuality, though, that this is not true since most drugs are not uniformly distributed. The liver plays a vital role in the drug metabolism. … View Answer, 4. 1. Who has more intracellular and extracellular water more in their body? 10. c) The basic drugs will aggregate and become poisonous for him Question # 17 (Multiple Answer) Factor(s) which effect a drug's volume of distribution: A) patient's gender B) patien'ts age C) presence of disease D) drug pKa E) extent of drug-plasma protein binding. A 34-year-old patient is about to receive a morphine injection because of a sharp abdominal pain apparently due to a renal colic. For attempting MCQs test on tablets first enter your name and email address and after completion please don't forget to press "Submit" button. The concept volume of distribution is also discussed, with a variety of medication examples. View Answer, 9. d) Bone d. Undergoes microsomal oxidation in the kidney. This set of Drug Biotechnology Multiple Choice Questions & Answers (MCQs) focuses on “Drug Distribution – Affecting Factors”. b) The patient can’t be given with basic drugs The drug distribution is based on the plasma protein binding, molecular size, and lipid solubility. 15-b) a drug with a different pharmacological mechanism of action 16-a) ionized drugs are likely to cross into the CSF than unionized drugs 17-b) Drug B and C have equal efficacy 18-a) Acetylation 19-b) 4-5 half-lives 20-d) A drug needed for treatment or prevention of a rare disease These drugs are never administered to infants less than 2 months of age because sulfonamides compete with bilirubin for binding to albumin. The process of transferring a drug from the bloodstream to tissues is referred to as distribution. Multiple Choice Questions Tablet . Non-specific binding to drugs can also play a role in drug-drug interactions; if two or more drugs are competing for the same binding site, one drug will displace the other, thereby, leading to potential toxicity caused by the drug that was displaced. Distribution of drug in aq phase o As Ko/w i.e. 28th November 2006. also govern the rate and extent that a drug will distribute to various tissues in the body. 5 L) largely stay in the plasma compartment. © 2011-2021 Sanfoundry. b) He cannot absorb lipophilic drugs 3) MCQ Test on Preservation of Cultures. a) The patient can’t be given with acidic drugs a) Infants MCQ Questions for Class 8 Science with Answers were prepared based on the latest exam pattern. a) Fat and bone heart, kidneys) than to areas that receive little blood flow (e.g. The Pharmacology Education Project (PEP) is being developed by The International Union of Basic and Clinical Pharmacology (IUPHAR), with support from sponsors, as a service to the international pharmacology community. latest staff nurse recruitment staff nurse papers exam. Mcq On Absorption And Distribution Of Drugs physicists continue work to abolish time as fourth. That is because the large proteins to which they are bound will not be able to readily distribute to other parts of the body. When drugs bind non-specifically to proteins, their movement is limited. 11. In addition, there are additional factors at play, particularly non-specific binding to proteins. Another way to think about Vd is that Vd is equal to the amount of space that a drug must fill up such that a given dose of a drug will achieve a specific plasma concentration. Flumazenil. Users can change the parameters in each module using sliders. Sample MCQ Questions PHARMACEUTICAL CHEMISTRY 1 Which is NOT true for the substance with the following chemical structure? pharma jobs and vacancies pharmaceutical jobs pharmatutor. Disease state of a patient can influence drug distribution across the body. D) a function of the physiologic volume of blood and tissues and how the drug binds in blood and tissues. The pharmacokinetic process is concerned with the absorption, distribution and elimination of drugs. After a drug enters the blood, it is distributed to various other tissues. This content applies to human and veterinary medicines. b) Tissue volume, tissue/blood partition coefficient of drug The volume of distribution is: A) dependent on the value of clearance. MCQ Base Clinical Pharmacology . Drugs that have relatively small Vd (e.g. [C] Formulation Factors:- 1. The guidance provided by the working group in the form of questions and answers (Q&As) provides … 2) MCQ Test on History of Microbiology. C 4. When considering the distribution of drugs to human milk which of the following is true? Drug distribution is the process of delivering a drug from the bloodstream to the tissues of the body – especially the tissue(s) where its actions are needed. B 14. c) The surface area increases in the mother’s body due to the presence of uterus, placenta, and foetus. C 5. Is less lipid soluble than lorazepam. 2) MCQ Test on History of Microbiology. Chloroquine. E) a and b. What is the half life of a drug with a volume of distribution of 700l/70kg and clearance of 49l/hour/70kg? c) Infants This 2 page article describes the concepts of volume of distribution, the significance of drug binding non-specifically to proteins and tissues, and properties of drugs that readily penetrate the blood-brain barrier. Question # 1 (Multiple Choice) Type of "chemical force" or bond that may drive the interaction between lipophilic drugs and biological membrane lipids: A) covalent B) electrostatic C) hydrophobic Question # 2 (Multiple Choice) Example(s) of a covalent drug-receptor interaction: A) receptor-activated phenoxybenzamine B) DNA-anticancer alkylating agent C) … C 12. b) Adults Of age more than 20 View Answer, 10. 4) MCQ Test on Manufacturing Defects of Tablets . lipid solubility i.e. Pharma Quiz Hub Register and Join Forum You can test your knowledge by just clicking START button below. “re-distribution”). Pharmaceutics MCQs Pharmaceutics MCQs You may also like, 1) MCQ Test on Microscopy. The third module relates VD concepts to the human body; for drugs with a large VD, users can observe how drugs distribute outside the bloodstream whereas drugs with a small VD stay mainly in the vasculature. C . d. Warfarin e. Digoxin Pharmacology Answers 1. 7. partition coefficient increases percentage drug absorbed increases. Which one of the following has very low perfusion rate? Check the below NCERT MCQ Questions for Class 8 Science Chapter 2 Microorganisms: Friend and Foe with Answers Pdf free download. Regarding circulating body fluids a. Drugs with a  Vd > 40 L distribute throughout all body tissues (vascular, extracellular, and intracellular fluid compartments). e. Is mainly metabolised to desmethyl diazepam. The protein acts as a “reservoir” of sorts. The volume of distribution of a drug: a. All of the following are general mechanisms of drug permeation Except (a) Aqueous diffusion (b) Aqueous hydrolysis (c) Lipid diffusion (d) Pinocytosis or endocytosis (e) Special carrier transport 2. b) False Skin c ) a function of the following drugs has the smallest volume of distribution of 700l/70kg and clearance 49l/hour/70kg! 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